“Western” moral assumptions permeate the debate over how to use cell-free DNA screening to identify genetic conditions in a developing fetus. In different cultures and contexts, however, different moral concerns may arise. While its implementation has raised both challenges and opportunities, very little is known about real-world experiences and the implications of the rapid introduction of cell-free DNA screening outside of North America and Europe, especially in low- and middle-income countries. Here, the organizers of an international, interdisciplinary workshop on cell-free DNA screening highlight eight key insights that arose during the workshop’s discussions.